PE-22-28
Price range: £18.00 through £70.00
CAS No: On request
Strengths Available: 5mg/10mg
Format: Sealed containment / vial presentations available
Volume: 3mL
What This Product Is About
PE-22-28 is frequently referenced in research focused on neurological signalling, cognition, and neuroprotection. It has attracted scientific attention as a research tool for exploring how neural and cognitive pathways respond under controlled conditions.
Description
What is PE-22-28?
PE-22-28 is a research-grade peptide studied in the context of neurological and cognitive-science research. Investigators have explored how PE-22-28 interacts with pathways relevant to neuroprotection, neurotransmitter modulation, or neural plasticity in laboratory models.
Why Researchers Became Interested in PE-22-28
Researchers became interested in PE-22-28 because of its relevance to neurological-signalling and cognitive research.
It provides a defined research tool for examining neural pathways in experimental models.
Key Research Focus Areas
- Neurological signalling and neuroprotection models
- Cognition and memory research
- Neurotransmitter-modulation studies
- Neural plasticity and growth-factor research
- Receptor-binding and pathway investigations
- Stress-response and neuro-recovery research
What the Research Has Shown
In preclinical research, PE-22-28 has been studied for its influence on neurological-signalling and neuroprotective pathways. Mechanistic studies have explored its interaction with pathways relevant to cognition and neural maintenance.
Scientific Background and Research Context
PE-22-28 is a synthetic seven-amino-acid peptide developed from a shortened region of spadin, a peptide associated with sortilin processing. It has been studied primarily in preclinical neuroscience research because of its interaction with the TREK-1 potassium channel, a membrane channel involved in neuronal excitability and mood-related signalling.
Researchers developed PE-22-28 to examine whether a shorter peptide sequence could retain or improve the biological activity observed with spadin. Laboratory findings suggest that PE-22-28 displays strong affinity for TREK-1 and may remain active for longer than the original peptide in experimental models.
Exploring the Science Behind
TREK-1 is a two-pore-domain potassium channel that helps regulate the electrical activity of neurons. PE-22-28 is studied as a TREK-1 inhibitor, meaning that it may alter potassium movement across neuronal membranes and influence downstream signalling pathways.
Preclinical studies have examined its effects in behavioural models related to mood and stress response. Researchers have also investigated whether TREK-1 inhibition may affect neuroplasticity and hippocampal neurogenesis, which refers to the formation of new neurons in a brain region involved in learning, memory and emotional regulation.
Research Context in Endocrine and Metabolic Science
Although PE-22-28 is mainly studied in neuroscience, its research context may overlap with endocrine and metabolic science because stress signalling, mood regulation, sleep, energy balance and neuroendocrine function are closely connected.
The TREK-1 channel is expressed in several tissues and participates in cellular responses to mechanical, chemical and metabolic conditions. Research into PE-22-28 may therefore contribute to a broader understanding of how neuronal ion channels interact with stress-related hormonal pathways and whole-body physiological regulation.
However, the available evidence remains predominantly preclinical, and its relevance to broader endocrine or metabolic processes has not been fully established.
Ongoing Scientific Interest
PE-22-28 continues to attract scientific interest as a compact peptide model for studying TREK-1 inhibition, antidepressant-like activity and neuroplasticity. Researchers are particularly interested in its potency, duration of action and comparison with spadin and other modified analogues.
Current findings are based mainly on cellular and animal studies. Further research is needed to determine its selectivity, pharmacological profile, long-term biological effects and potential relevance to human physiology.
PE-22-28 is supplied strictly for laboratory and research purposes and is not intended for human consumption or therapeutic use.
Ingredient Profile
Single research compound: PE-22-28
CAS: On request
Purity >99%
Supplied as lyophilised powder (no excipients, fillers or additives).
Active Ingredients
PE-22-28 — 5mg/10mg
Ingredient Breakdown
PE-22-28: 5mg/10mg of active peptide per vial (lyophilised).
Why is PE-22-28 studied in cognitive research?
Because studies have explored its relevance to neurological signalling, cognition, and neuroprotection.
Is PE-22-28 approved for medical use?
No. It is supplied strictly for research and laboratory use only, and is not intended for human or veterinary use.
Why does purity matter so much for this product?
High purity helps ensure that observed research effects are due to the material itself rather than impurities.
What does ‘research grade’ mean?
It means the product is supplied with documentation and traceability for laboratory investigation.
Is international supply available?
Yes. International fulfilment and temperature-controlled shipping can be supported where appropriate.
Research & laboratory use only. Not for human or veterinary use. Not a medicinal product, supplement, food or medical device. No therapeutic, diagnostic, cosmetic, wellness or lifestyle claims are made or implied. Analytical reference/click information is a laboratory measurement aid only and must not be applied to living systems.
Typically supplied at >99% purity, supported by batch-specific analytical data. UK-based preparation, analysis and release under scientist-led, GMP-aligned processes with full batch-level traceability. Certificate of Analysis (CoA) available on request; independent analytical verification where appropriate.
Store the lyophilised powder refrigerated at 2–8°C, protected from light and moisture; suitable for longer-term storage frozen at -20°C. Handle under appropriate laboratory conditions. For in vitro research use only.
For in vitro laboratory research only. Reconstitution, handling and experimental design at the discretion of the qualified researcher. The 300-click sealed-containment system is an analytical measurement reference only and does not represent dosing or administration guidance. Not for use in living systems.
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