CJC‑1295 (No DAC)
Price range: £15.00 through £42.00
CAS No: 863288-34-0
Strengths Available: 5mg / 10mg
Format: Sealed containment / vial presentations available
Volume: 3mL
What This Product Is About
CJC-1295 (No-DAC) is widely referenced in research settings as a short-acting analogue of Growth Hormone Releasing Hormone (GHRH). Unlike its Drug Affinity Complex (DAC) counterpart, this version is designed to produce brief, pulse-like growth hormone signalling.
Because it does not contain a DAC, it clears from circulation more quickly. This makes it particularly useful for studies examining natural growth hormone pulses and timing.
Description
What Is CJC 1295 ?
CJC 1295 Is a research-grade peptide studied in the
context of growth hormone secretagogue and GH-axis signalling research. Investigators have explored how CJC 1295 No DAC interacts with receptors and pathways involved in the regulation of growth hormone and downstream IGF activity.
Why Researchers Became Interested in CJC 1295
Researchers became interested in CJC 1295 No DAC because of its relevance to GH-axis regulation and the broader study of metabolic and recovery pathways. It provides a defined research tool for examining growth-factor signalling in experimental models.
Key Research Focus Areas
- Growth hormone secretagogue signalling models
- GH / IGF-1 axis regulation studies
- Metabolic and body-composition research models
- Receptor-binding and pathway studies
- Recovery and tissue-maintenance research
- Endocrine signalling investigations
What the Research Has Shown
In preclinical research, CJC 1295 No DAC has been studied for its influence on growth hormone signalling pathways and related downstream activity.
Mechanistic studies have explored its interaction with receptors involved in the regulation of the GH-axis.
Scientific Background and Mechanism of Action
CJC-1295 (No DAC) is a modified 29-amino acid peptide derived from GHRH (1-29) with enhanced stability and affinity for the GHRH receptor. Upon binding to its receptor on pituitary somatotrophs, it activates adenylate cyclase and cAMP signalling pathways, leading to a natural, transient release of growth hormone. Its short half-life mimics physiological GH pulses seen in circadian rhythms — a key advantage for research that seeks to preserve feedback integrity and avoid receptor down-regulation. Compared to the DAC form, which prolongs GH release through albumin binding, the No DAC variant is preferred in studies examining natural pulsatility and GH feedback loops under short-duration kinetics.
Synergy with Ipamorelin
CJC-1295 (No DAC) and Ipamorelin form a gold-standard research pair within the GH axis model. While CJC-1295 acts as a GHRH analogue stimulating the hypothalamus and pituitary, Ipamorelin functions as a ghrelin receptor agonist directly on the pituitary to release GH. This dual-pathway activation creates a synergistic and physiological GH pulse, replicating the endocrine rhythm observed in healthy biological systems. The combination has become the benchmark in controlled laboratory research examining GH secretion, IGF-1 production, metabolic homeostasis, and anabolic gene activation. When paired, CJC-1295 (No DAC) provides the rhythmic GHRH stimulation while Ipamorelin enhances amplitude and frequency of GH release without affecting cortisol or prolactin levels.
Formats Available
| Format | Volume | Strength | Purity | Description |
| 300-Click Precision Dial-Click sealed containment device | 3ml | 5/10mg | >99% | Pre-mixed & pre-filled precision sealed containment device. containing 300 calibrated clicks for precise and reproducible laboratory use. |
Ingredient Profile
Single research compound: CJC-1295 (No DAC). CAS: 863288-34-0. Purity >99%. Supplied as lyophilised powder (no excipients, fillers or additives).
Active Ingredients
CJC-1295 (No DAC) — 5mg / 10mg
Ingredient Breakdown
CJC-1295 (No DAC): 5mg / 10mg of active peptide per vial (lyophilised).
Why is CJC 1295 No DAC studied in growth-hormone research?
Because studies have explored its relevance to growth hormone and IGF-axis signalling pathways.
Is CJC 1295 No DAC approved for medical use?
No. It is supplied strictly for research and laboratory use only, and is not intended for human or veterinary use.
Why does purity matter so much for this product?
High purity helps ensure that observed research effects are due to the material itself rather than impurities.
What does ‘research grade ‘ mean?
It means the product is supplied with documentation and traceability for laboratory investigation.
Is international supply available?
Yes. International fulfilment and temperature-controlled shipping can be supported where appropriate.
Research & laboratory use only. Not for human or veterinary use. Not a medicinal product, supplement, food or medical device. No therapeutic, diagnostic, cosmetic, wellness or lifestyle claims are made or implied. Analytical reference/click information is a laboratory measurement aid only and must not be applied to living systems.
Typically supplied at >99% purity, supported by batch-specific analytical data. UK-based preparation, analysis and release under scientist-led, GMP-aligned processes with full batch-level traceability. Certificate of Analysis (CoA) available on request; independent analytical verification where appropriate.
Store the lyophilised powder refrigerated at 2–8°C, protected from light and moisture; suitable for longer-term storage frozen at -20°C. Handle under appropriate laboratory conditions. For in vitro research use only.
For in vitro laboratory research only. Reconstitution, handling and experimental design at the discretion of the qualified researcher. The 300-click sealed-containment system is an analytical measurement reference only and does not represent dosing or administration guidance. Not for use in living systems.
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