ARA-290 (Cibinetide)
Price range: £15.00 through £50.00
CAS No: 1208243-50-8
What is ARA-290 about?
Strengths Available: 10mg/16mg
Format: Sealed containment / vial presentations available
Volume: 3mL
ARA-290 is a research-grade peptide studied in the context of metabolic signalling, energy balance, and related receptor pathways. Investigators have explored how ARA-290 interacts with pathways relevant to glucose handling, appetite regulation, or lipid metabolism in laboratory models.
Description
What is ARA-290?
ARA-290 is frequently referenced in research focused on metabolic regulation, energy balance, and body-composition science. It has attracted scientific attention as a research tool for exploring how metabolic and appetite-signalling pathways are regulated. What Is ARA-290? ARA-290 is a research-grade peptide studied in the context of metabolic signalling, energy balance, and related receptor pathways. Investigators have explored how ARA-290 interacts with pathways relevant to glucose handling, appetite regulation, or lipid metabolism in laboratory models.
Why ARA-290 Attracted Research Interest
Researchers became interested in ARA-290 because of its relevance to metabolic regulation and the study of energy-balance pathways. It provides a defined research tool for examining metabolic signalling in experimental models.4
Key Research Focus Areas
- Metabolic and energy-balance signalling models
- Glucose and lipid metabolism research
- Appetite and satiety pathway studies
- Receptor-binding and pathway investigations
- Body-composition research models
- Mitochondrial and cellular-energy research
What the Research Has Shown
In preclinical research, ARA-290 has been studied for its influence on metabolic signalling and energy-balance pathways.
Mechanistic studies have explored its interaction with receptors and pathways central to metabolic regulation.
Scientific Background and Research Context
ARA-290, also known as cibinetide, is a synthetic peptide derived from the tissue-protective region of erythropoietin, commonly known as EPO. Unlike full erythropoietin, ARA-290 was engineered to avoid erythropoietic activity, meaning it is not intended to stimulate red blood cell production. Instead, it has been studied for its potential role in tissue protection, anti-inflammatory signalling, and nerve-repair pathways.
ARA-290 attracted scientific attention because researchers identified that erythropoietin may have tissue-protective effects separate from its role in red blood cell production. ARA-290 was designed to explore this non-hematopoietic pathway while reducing the broader biological effects associated with full EPO.
In research settings, ARA-290 has been investigated for its relationship to:
- Small fiber neuropathy
- Inflammatory tissue stress
- Nerve repair and regeneration
- Diabetic neuropathy
- Sarcoidosis-associated neuropathic symptoms
- Metabolic and neuroprotective pathways
Exploring the Science Behind GLP-1
A central area of ARA-290 research involves the innate repair receptor, sometimes described as a tissue-protective receptor complex involving the erythropoietin receptor and the beta-common receptor, also known as CD131. Activation of this pathway has been studied in relation to cytoprotection, anti-inflammatory responses, and tissue repair.
This is scientifically important because it separates ARA-290 from traditional EPO biology. Rather than focusing on erythropoiesis, researchers have explored whether ARA-290 may influence local repair responses after inflammatory or metabolic injury.
Research Context in Metabolic and Body-Composition Science
ARA-290 has been studied most prominently in neuropathy-related research. In sarcoidosis patients with symptoms of small fiber neuropathy, early clinical studies examined whether ARA-290 could reduce neuropathic symptoms and support small nerve fiber repair. A pilot study described ARA-290 as a peptide designed to activate the innate repair receptor, with effects related to cytoprotection, anti-inflammation, and healing.
It has also been studied in type 2 diabetes research, where investigators examined both metabolic control and neuropathic symptoms. A 2015 study reported that ARA-290 may benefit metabolic control and neuropathy in subjects with type 2 diabetes, while noting that continued clinical evaluation was warranted.
Ongoing Scientific Interest
Ongoing interest in ARA-290 comes from its potential value as a research tool for understanding how inflammatory signalling, tissue stress, and nerve injury interact. Research has explored its possible relevance in neuro protection, corneal nerve fiber density, ocular discomfort, and tissue repair pathways. A Phase 2 study of cibinetide in diabetic macular edema reported improvements in tear production and ocular pain-related measures in patients with reduced basal tear formation.
Overall, ARA-290 is best understood as a research peptide connected to EPO-derived tissue-protective signalling, rather than as a traditional growth, metabolic, or hormone peptide.
For research and laboratory use only. Not for human or veterinary use.
Ingredient Profile
Single research compound: ARA-290. CAS: 1208243-50-8. Purity >99%. Supplied as lyophilised powder (no excipients, fillers or additives).
Active Ingredients
ARA-290 — 16mg
Ingredient Breakdown
ARA-290: 16mg of active peptide per vial (lyophilised).
Why is ARA-290 studied in metabolic research?
Because studies have explored its relevance to metabolic regulation and energy-balance pathways.
Is ARA-290 approved for medical use?
No. It is supplied strictly for research and laboratory use only, and is not intended for human or veterinary use.
Why does purity matter so much for this
product?
High purity helps ensure that observed research effects are due to the material itself rather than impurities.
What does ‘research grade’ mean?
It means the product is supplied with documentation and traceability for laboratory investigation.
Is international supply available?
Yes. International fulfilment and temperature-controlled shipping can be supported where appropriate.
Research & laboratory use only. Not for human or veterinary use. Not a medicinal product, supplement, food or medical device. No therapeutic, diagnostic, cosmetic, wellness or lifestyle claims are made or implied. Analytical reference/click information is a laboratory measurement aid only and must not be applied to living systems.
Typically supplied at >99% purity, supported by batch-specific analytical data. UK-based preparation, analysis and release under scientist-led, GMP-aligned processes with full batch-level traceability. Certificate of Analysis (CoA) available on request; independent analytical verification where appropriate.
Store the lyophilised powder refrigerated at 2–8°C, protected from light and moisture; suitable for longer-term storage frozen at -20°C. Handle under appropriate laboratory conditions. For in vitro research use only.
For in vitro laboratory research only. Reconstitution, handling and experimental design at the discretion of the qualified researcher. The 300-click sealed-containment system is an analytical measurement reference only and does not represent dosing or administration guidance. Not for use in living systems.
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