Klotho
CAS No: No single universally established CAS number
Strengths Available: 3.5 pg
Format: Sealed containment / vial presentations available
Volume: 3mL
What This Product Is About
Klotho is a naturally occurring protein strongly associated with kidney function, mineral metabolism and aging biology. It acts both as a membrane protein and as a circulating soluble protein.
Description
What Is Klotho?
Klotho is a regulatory protein that works with fibroblast growth factor 23 (FGF23) to control phosphate and vitamin D metabolism and is widely studied in aging and kidney research.
Why Researchers Became Interested in Klotho
Researchers became interested in Klotho after animal studies linked reduced Klotho activity with premature aging-like changes. This led to research into its roles in longevity, kidney disease, cardiovascular biology and cellular protection.
Key Research Focus Areas
- Aging and longevity
- Kidney function
- FGF23 signalling
- Phosphate metabolism
- Vitamin D regulation
- Cardiovascular research
- Oxidative stress
- Neurodegenerative research
What the Research Has Shown
Research shows that Klotho is important for FGF23 signalling and mineral balance. Reduced Klotho levels are associated with chronic kidney disease and several aging-related biological changes. Potential therapeutic applications remain under investigation.
Scientific Background and Research Context
Klotho is a naturally occurring protein involved in ageing, mineral balance and endocrine signalling, particularly through fibroblast growth factor pathways.
Exploring the Science Behind
Research focuses on its role in FGF23 signalling, phosphate regulation, cellular protection and metabolic pathways.
Research Context in Endocrine and Metabolic Science
Klotho is studied in relation to mineral metabolism, glucose regulation, kidney function and age-related metabolic changes.
Ongoing Scientific Interest
Scientific interest continues around its potential influence on healthy ageing, metabolic health, inflammation and cellular resilience.
Ingredient Profile
Single research compound: Klotho
CAS: No single universally established CAS number
Supplied as lyophilised powder (no excipients, fillers or additives).
Active Ingredients
Klotho — 3.5 pg
Ingredient Breakdown
Klotho : 3.5 pg of active peptide per vial (lyophilised).
Why is Klotho studied in metabolic research?
Klotho is studied because it influences phosphate, calcium and vitamin D metabolism and forms part of the FGF23–Klotho endocrine pathway.
Is Klotho approved for medical use?
No. Recombinant Klotho is not currently approved as a routine therapeutic medicine. Its potential clinical applications remain experimental.
Why does purity matter so much for this product?
High purity helps ensure reliable protein activity and reduces contaminants that could interfere with laboratory experiments.
What does “research grade” mean?
Research grade means the product is intended for laboratory or analytical research and does not mean it is pharmaceutical grade or suitable for human administration.
Is international supply available?
International availability depends on the supplier, destination country and regulations governing recombinant proteins and research biological materials.
Research & laboratory use only. Not for human or veterinary use. Not a medicinal product, supplement, food or medical device. No therapeutic, diagnostic, cosmetic, wellness or lifestyle claims are made or implied. Analytical reference/click information is a laboratory measurement aid only and must not be applied to living systems.
Typically supplied at >99% purity, supported by batch-specific analytical data. UK-based preparation, analysis and release under scientist-led, GMP-aligned processes with full batch-level traceability. Certificate of Analysis (CoA) available on request; independent analytical verification where appropriate.
Store the lyophilised powder refrigerated at 2–8°C, protected from light and moisture; suitable for longer-term storage frozen at -20°C. Handle under appropriate laboratory conditions. For in vitro research use only.
For in vitro laboratory research only. Reconstitution, handling and experimental design at the discretion of the qualified researcher. The 300-click sealed-containment system is an analytical measurement reference only and does not represent dosing or administration guidance. Not for use in living systems.
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