PT-141
Price range: £10.00 through £30.00
CAS No: 189691-06-3
Strengths Available: 10mg
Format: Sealed containment / vial presentations available
Volume: 3mL
What This Product Is About
PT-141 is a synthetic peptide derived from alpha-melanocyte-stimulating hormone (α-MSH) that has generated sustained interest in research communities because of how it allows scientists to explore behavioural, motivational, and neuroendocrine signalling at a central nervous system level.
Although PT-141 is often discussed in public forums in relation to sexual desire, its scientific value lies in what it enables researchers to observe under controlled laboratory conditions—specifically how melanocortin receptor pathways influence behaviour, arousal, and autonomic response.
Description
What is PT-141?
PT-141 is a small synthetic peptide designed to interact with melanocortin receptors in the brain. These receptors play a role in motivation, reward, arousal, and behavioural response.
In simple terms, PT-141 helps researchers study how certain brain pathways influence desire and behavioural signalling without acting through blood flow or peripheral vascular mechanisms.
Why PT-141 Attracted Research Interest
Scientific interest in PT-141 stems from its central mechanism of action. Unlike compounds that affect peripheral systems, PT-141 allows researchers to study behaviour-related signalling directly at the brain-receptor level.
- Central melanocortin receptor signalling
- Behavioural and motivational pathway research
- Neuroendocrine regulation of arousal and desire
- Autonomic nervous system signalling
- Distinguishing central versus vascular mechanisms
Key Research Focus Areas
- Reproductive and endocrine signalling models
- Hormonal-axis regulation studies
- Receptor-binding and pathway investigations
- Behavioural and neuroendocrine research
- Sexual-health research models
- Hypothalamic–pituitary signalling research
What the Research Has Shown
In preclinical research, PT-141 has been studied for its influence on reproductive and hormonal-signalling pathways. Mechanistic studies have explored its interaction with receptors central to endocrine regulation.
Scientific Background and Mechanism of Action
PT-141 is derived from Melanotan II and functions as a melanocortin receptor agonist. Unlike vasodilators that target the vascular system, PT-141 activates neuronal pathways in the hypothalamus to initiate behavioural and neuroendocrine responses. The compound selectively binds to MC4R and MC3R receptors, which are key regulators of sexual function, motivation, and energy balance.
Activation of these receptors leads to the release of neurotransmitters such as dopamine and nitric oxide within the CNS, facilitating central neural activation without significant peripheral effects. This mechanistic distinction has positioned PT-141 as a cornerstone molecule in neuroendocrine and behavioural research models.
PT-141, also known as bremelanotide, is a synthetic peptide analogue derived from alpha-melanocyte-stimulating hormone, commonly written as α-MSH. It belongs to a class of compounds known as melanocortin receptor agonists, which are studied for their effects on central nervous system signalling, sexual-response pathways, and neuroendocrine regulation. The FDA review for Vyleesi identifies bremelanotide as PT-141 and describes it as a peptide analogue of α-MSH.
PT-141 attracted research attention because it works through the melanocortin system, rather than through the vascular nitric-oxide pathway targeted by many erectile-dysfunction drugs. This made it scientifically interesting for studying sexual arousal, desire, central nervous system signalling, and brain-mediated reproductive behaviour. Unlike compounds that primarily act on blood flow, PT-141 has been investigated for its effects on neural pathways involved in sexual motivation and arousal. This gave researchers a different model for exploring sexual function, particularly where desire and central arousal mechanisms are more relevant than peripheral circulation.
Exploring the Science Behind Melanocortin Receptors
The melanocortin system includes several receptor subtypes involved in pigmentation, appetite regulation, inflammation, energy balance, and sexual behaviour. Bremelanotide is described in the FDA label as a melanocortin receptor agonist that nonselectively activates several melanocortin receptor subtypes. PT-141 is especially associated with research into MC3R and MC4R signalling, which are receptor pathways expressed in areas of the brain linked to neuroendocrine and behavioural regulation. Because of this, PT-141 has been used as a research tool to study how melanocortin signalling may influence arousal, desire, and reproductive behaviour.
Medical Approval Context
Bremelanotide is approved in the United States as Vyleesi for the treatment of acquired, generalized hypoactive sexual desire disorder in premenopausal women. It is not approved as a general libido enhancer, and it is not approved for use in men. For research-product wording, a safer phrasing would be: PT-141 is a melanocortin-receptor research peptide studied for its role in central sexual-response signalling and neuroendocrine pathways. Where supplied as a research material, it is intended for research and laboratory use only.
Not for human or veterinary use.
Ingredient Profile
Single research compound: PT-141
CAS: 189691-06-3
Purity >99%
Supplied as lyophilised powder (no excipients, fillers or additives).
Active Ingredients
PT-141 — 10mg
Ingredient Breakdown
PT-141: 10mg of active peptide per vial (lyophilised).
Why is PT-141 studied in hormonal-signalling research?
Because studies have explored its relevance to reproductive and hormonal-signalling pathways.
Is PT-141 approved for medical use?
No. It is supplied strictly for research and laboratory use only, and is not intended for human or veterinary use.
Why does purity matter so much for this product? High purity helps ensure that observed research effects are due to the material itself rather than impurities.
What does ‘ research grade ‘ mean?
It means the product is supplied with documentation and traceability for laboratory investigation.
Is international supply available?
Yes. International fulfilment and temperature-controlled shipping can be supported where appropriate.
Research & laboratory use only. Not for human or veterinary use. Not a medicinal product, supplement, food or medical device. No therapeutic, diagnostic, cosmetic, wellness or lifestyle claims are made or implied. Analytical reference/click information is a laboratory measurement aid only and must not be applied to living systems.
Typically supplied at >99% purity, supported by batch-specific analytical data. UK-based preparation, analysis and release under scientist-led, GMP-aligned processes with full batch-level traceability. Certificate of Analysis (CoA) available on request; independent analytical verification where appropriate.
Store the lyophilised powder refrigerated at 2–8°C, protected from light and moisture; suitable for longer-term storage frozen at -20°C. Handle under appropriate laboratory conditions. For in vitro research use only.
For in vitro laboratory research only. Reconstitution, handling and experimental design at the discretion of the qualified researcher. The 300-click sealed-containment system is an analytical measurement reference only and does not represent dosing or administration guidance. Not for use in living systems.
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