ACE-083
CAS No: 1644543-31-6
Format: Sealed containment / vial presentations available
Volume: 3 mL
What This Product Is About
ACE-083 is an investigational protein designed to increase muscle growth locally by blocking signalling molecules such as myostatin and activins.
Description
What Is ACE-083?
ACE-083 is a follistatin-based Fc fusion protein that acts as a local ligand trap for members of the TGF-β protein family involved in limiting skeletal muscle growth.
Why Researchers Became Interested in ACE-083
Researchers became interested in ACE-083 because it offered a way to increase the size of specific muscles without producing the same degree of systemic exposure expected from whole-body muscle-growth therapies.
Key Research Focus Areas
- Skeletal muscle growth
- Myostatin and activin signalling
- Muscular dystrophy
- Charcot-Marie-Tooth disease
- Muscle volume and strength
- Localised muscle regeneration
What the Research Has Shown
Phase 2 studies found that ACE-083 could increase muscle volume, but these increases did not consistently lead to meaningful improvements in physical function. The clinical development programme was subsequently discontinued.
Scientific Background and Research Context
ACE-083 is an investigational follistatin-based fusion protein studied for its effects on skeletal muscle growth.
Exploring the Science Behind
Research has focused on its interaction with myostatin, activins and related TGF-β signalling pathways involved in muscle regulation.
Research Context in Endocrine and Metabolic Science
ACE-083 has been investigated in relation to muscle mass, muscle function and neuromuscular disorders.
Ongoing Scientific Interest
Scientific interest centres on understanding how locally targeted modulation of muscle-growth pathways may influence muscle volume and function.
Ingredient Profile
Single research compound: ACE-083
CAS: 1644543-31-6
Purity >99%
Supplied as lyophilised powder (no excipients, fillers or additives).
Active Ingredients
ACE-083 — 1/2/3 mg
Ingredient Breakdown
ACE-083 : 1/2/3 mg of active peptide per vial (lyophilised).
Why is ACE-083 studied in metabolic research?
ACE-083 is mainly studied in muscle biology and neuromuscular research, particularly pathways controlling muscle growth, regeneration and protein signalling.
Is ACE-083 approved for medical use?
No. ACE-083 remains an investigational compound and is not an approved medicine. Its Phase 2 development programme was discontinued after functional endpoints were not achieved.
Why does purity matter so much for this product?
Because ACE-083 is a complex biologic protein, purity and structural integrity are important for obtaining reliable and reproducible research results.
What does “research grade” mean?
Research grade means the material is intended for laboratory or analytical research and does not mean it is approved or suitable for human administration.
Is international supply available?
International availability depends on the supplier, destination country and applicable rules governing the import and supply of research biologics.
Research & laboratory use only. Not for human or veterinary use. Not a medicinal product, supplement, food or medical device. No therapeutic, diagnostic, cosmetic, wellness or lifestyle claims are made or implied. Analytical reference/click information is a laboratory measurement aid only and must not be applied to living systems.
Typically supplied at >99% purity, supported by batch-specific analytical data. UK-based preparation, analysis and release under scientist-led, GMP-aligned processes with full batch-level traceability. Certificate of Analysis (CoA) available on request; independent analytical verification where appropriate.
Store the lyophilised powder refrigerated at 2–8°C, protected from light and moisture; suitable for longer-term storage frozen at -20°C. Handle under appropriate laboratory conditions. For in vitro research use only.
For in vitro laboratory research only. Reconstitution, handling and experimental design at the discretion of the qualified researcher. The 300-click sealed-containment system is an analytical measurement reference only and does not represent dosing or administration guidance. Not for use in living systems.
Partner with FreshstartPharma– Where Accuracy Meets Innovation
Freshstartpharma is committed to delivering high-quality research-grade products designed for advanced scientific applications. We offer wholesale partnerships to selected businesses that share our values of integrity, quality, and innovation. Whether you’re an established distributor or an emerging research supply company, we invite you to join our network and benefit from exclusive access to our state-of-the-art product range.
