ATX-GD-59
CAS No: No single CAS number is commonly assigned to ATX-GD-59 because it is an equimolar mixture of two synthetic peptides, rather than one defined chemical substance.
Strengths Available: 1.6 mg
Format: Sealed containment / vial presentations available
Volume: 3 mL
What This Product Is About
ATX-GD-59 is an investigational antigen-specific peptide immunotherapy developed for research into Graves’ disease and autoimmune thyroid disorders.
Description
What Is ATX-GD-59?
ATX-GD-59 contains two synthetic peptides derived from the human thyroid-stimulating hormone receptor (TSHR). The peptides are designed to influence the immune response to TSHR without broadly suppressing the immune system.
Why Researchers Became Interested in ATX-GD-59
Researchers became interested in ATX-GD-59 because Graves’ disease is driven by an autoimmune response against the TSH receptor. ATX-GD-59 was designed to investigate whether immune tolerance could be restored in a more targeted way.
Key Research Focus Areas
- Graves’ disease
- Autoimmune thyroid disease
- TSH receptor antibodies
- Immune tolerance
- Peptide immunotherapy
- Thyroid hormone regulation
What the Research Has Shown
A Phase I study involving people with Graves’ hyperthyroidism found that ATX-GD-59 was generally well tolerated. Seven of ten participants who completed treatment showed either complete or partial improvements in thyroid hormone levels, although the study was small and exploratory.
Scientific Background and Research Context
ATX-GD-59 is an investigational peptide-based immunotherapy developed from thyroid-stimulating hormone receptor (TSHR) sequences and studied in Graves’ disease.
Exploring the Science Behind
Research focuses on whether selected TSHR peptides can help promote antigen-specific immune tolerance without broad immunosuppression.
Research Context in Endocrine and Metabolic Science
ATX-GD-59 has been investigated in the context of autoimmune thyroid disease, hyperthyroidism and TSH-receptor autoantibody activity.
Ongoing Scientific Interest
Scientific interest centres on targeted immune-modulating approaches that may influence the autoimmune processes underlying Graves’ hyperthyroidism.
Ingredient Profile
Single research compound: ATX-GD-59
CAS: No single CAS number is commonly assigned to ATX-GD-59 because it is an equimolar mixture of two synthetic peptides, rather than one defined chemical substance.
Purity >99%
Supplied as lyophilised powder (no excipients, fillers or additives).
Active Ingredients
ATX-GD-59— 1.6 mg
Ingredient Breakdown
ATX-GD-59: 1.6 mg of active peptide per vial (lyophilised).
Why is ATX-GD-59 studied in metabolic research?
It is more specifically studied in thyroid and autoimmune research, particularly how immune responses influence thyroid hormone regulation.
Is ATX-GD-59 approved for medical use?
No. ATX-GD-59 remains an investigational therapy and has not been approved for general medical use.
Why does purity matter so much for this product?
High peptide purity is important for accurate and reproducible research and helps reduce interference from synthesis-related impurities.
What does “research grade” mean?
Research grade means the material is intended for laboratory or analytical research and is not automatically suitable or approved for human use.
Is international supply available?
Availability depends on the research supplier, destination country and applicable rules governing the import and supply of investigational peptides.
Research & laboratory use only. Not for human or veterinary use. Not a medicinal product, supplement, food or medical device. No therapeutic, diagnostic, cosmetic, wellness or lifestyle claims are made or implied. Analytical reference/click information is a laboratory measurement aid only and must not be applied to living systems.
Typically supplied at >99% purity, supported by batch-specific analytical data. UK-based preparation, analysis and release under scientist-led, GMP-aligned processes with full batch-level traceability. Certificate of Analysis (CoA) available on request; independent analytical verification where appropriate.
Store the lyophilised powder refrigerated at 2–8°C, protected from light and moisture; suitable for longer-term storage frozen at -20°C. Handle under appropriate laboratory conditions. For in vitro research use only.
For in vitro laboratory research only. Reconstitution, handling and experimental design at the discretion of the qualified researcher. The 300-click sealed-containment system is an analytical measurement reference only and does not represent dosing or administration guidance. Not for use in living systems.
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